Synthesis and anti-inflammatory activity of chalcone derivatives

6533b853fe1ef96bd12ac0f1

RESEARCH PRODUCT

Synthesis and anti-inflammatory activity of chalcone derivatives

M.luisa Ferrándiz M. José Alcaraz Jaime Charris Amalia Ubeda Gricela Lobo Josén. Domínguez Felipe Herencia

subject

Chalcone Neutrophils medicine.drug_class Leukotriene B4 Clinical Biochemistry Pharmaceutical Science Leukotriene B4 Biochemistry Chemical synthesis Anti-inflammatory Mice Structure-Activity Relationship chemistry.chemical_compound Chalcone In vivo Drug Discovery medicine Animals Humans Cyclooxygenase Inhibitors Lipoxygenase Inhibitors Molecular Biology Propiophenones Arachidonate 5-Lipoxygenase Cyclooxygenase 2 Inhibitors Molecular Structure Chemistry Superoxide Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Degranulation Membrane Proteins In vitro Isoenzymes Biochemistry Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Drug Design Molecular Medicine

description

Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4-7) inhibited cyclo-oxygenase-2 activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.

year	journal	country	edition	language
1998-05-01	Bioorganic & Medicinal Chemistry Letters

https://doi.org/10.1016/s0960-894x(98)00179-6

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