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RESEARCH PRODUCT
Encapsulation of folic acid in different silica porous supports: A comparative study.
Cristina De La TorreMaría Ruiz-ricoFélix SancenónPedro AmorósMaría D. MarcosRamón Martínez-máñezÉDgar Pérez-esteveJosé M. BaratLuis A. Villaescusasubject
OptimizationVitaminPorous silica supportsSmart deliveryINGENIERIA DE LA CONSTRUCCIONFolic acidTECNOLOGIA DE ALIMENTOSSilicon dioxideKinetics02 engineering and technology010402 general chemistryElectron Microscopy Service of the UPV01 natural sciencesAnalytical Chemistrychemistry.chemical_compoundQUIMICA ORGANICAFolic AcidNeutral phPorosityNutritionChemistryQUIMICA INORGANICAGeneral MedicineMesoporous silica021001 nanoscience & nanotechnologySilicon Dioxide0104 chemical sciencesLarge poreNutrition AssessmentBiochemistryChemical engineeringFolic acid0210 nano-technologyPorosityFood Sciencedescription
Although folic acid is essential to numerous bodily functions, recent research indicates that a massive exposition to the vitamin could be a double-edged sword. In this study, the capacity of different caped mesoporous silica particles (i.e. Hollow Silica Shells, MCM-41, SBA-15 and UVM-7) to dose FA during its passage through the gastrointestinal tract has been evaluated. Results confirmed that the four capped materials were capable to hinder the delivery of FA at low pH (i.e. stomach) as well as able to deliver great amounts of the vitamin at neutral pH (i.e. intestine). Nevertheless, the encapsulation efficiency and the deliver kinetics differed among supports. While supports with large pore entrance exhibited an initial fast release, MCM-41, showed a sustained release along the time. This correlation between textural properties and release kinetics for each of the supports reveals the importance of a proper support selection as a strategy to control the delivery of active molecules.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-04-01 | Food chemistry |