6533b853fe1ef96bd12acb10

RESEARCH PRODUCT

MICROWAVE EFFECTS ON ACETYLCHOLINE-INDUCED CHANNELS IN CULTURED CHICK MYOTUBES

Francesca GrassiP. BernardiGuglielmo D'inzeoBianca M. ZaniC. TamburelloFabrizio Eusebi

subject

PhysiologyMyogenesisChemistryMusclesBiophysicsPhase (waves)ConductanceChick EmbryoGeneral MedicineAnatomyIn Vitro TechniquesElectromagnetic radiationAcetylcholineIon ChannelsDesensitization (telecommunications)medicineBiophysicsAnimalsRadiology Nuclear Medicine and imagingacetylcholine receptor; microwave irradiationCurrent (fluid)MicrowavesMicrowaveAcetylcholinemedicine.drug

description

The behavior of cultured myotubes from chick embryos exposed to microwaves has been experimentally analyzed. Recordings of acetylcholine-induced currents have been obtained via patch-clamp techniques using both cell-attached (single-channel current recording) and whole-cell (total current recording) configurations. During the exposure to low-power microwaves the frequency of the ACh-activated single channel openings decreased, while the ACh-induced total current showed a faster falling phase. Channel open time and conductance were not affected by microwave irradiation. It is concluded that the exposure to microwaves increases the rate of desensitization and decreases the channel opening probability. The nonthermal origin and the molecular interaction mechanisms governing these electromagnetic-induced effects are discussed.

yearjournalcountryeditionlanguage
1988-01-01
10.1002/bem.2250090406http://hdl.handle.net/11573/457304