6533b853fe1ef96bd12acdaf
RESEARCH PRODUCT
Volatile organic compounds fingerprint of Alzheimer’s disease.
Ferdinando SartucciMieczyslaw PokorskiLuciano DomeniciAndrea MazzatentaCamillo Di Giuliosubject
AdultPulmonary and Respiratory MedicinePathologymedicine.medical_specialtyTime FactorsPhysiologyDiseaseVolatile organic compounds (VOCs)Neurodegenerative diseaseAlzheimer's disease; Breath analysis; Neurodegenerative disease; VOC fingerprint; VOC real time analysis; Volatile organic compounds (VOCs); Adult; Aged; Aged 80 and over; Alzheimer Disease; Biomarkers; Breath Tests; Humans; Middle Aged; Respiratory Rate; Time Factors; Volatile Organic Compounds; Young Adult; Neuroscience (all); Physiology; Pulmonary and Respiratory MedicineYoung AdultRespiratory RateAlzheimer DiseaseVOC fingerprintmedicine80 and overHumansDisease processScreening toolAgedAged 80 and overVolatile Organic CompoundsNeuroscience (all)ChemistryGeneral NeuroscienceLate stageBreath analysisAlzheimer's diseaseMiddle AgedAlzheimer's disease; Breath analysis; Neurodegenerative disease; VOC fingerprint; VOC real time analysis; Volatile organic compounds (VOCs)Breath gas analysisBreath TestsImmunologyVOC real time analysisBiomarkersdescription
Alzheimer's disease (AD) is a profoundly life changing condition and once diagnosis occurs, this is typically at a relatively late stage into the disease process. Therefore, a shift to earlier diagnosis, which means several decades before the onset of the typical manifestation of the disease, will be an important step forward for the patient. A promising diagnostic and screening tool to answer this purpose is represented by breath and exhaled volatile organic compounds (VOCs) analysis. In fact, human exhaled breath contains several thousand of VOCs that vary in abundance and number in correlation with the physiological status. The exhaled VOCs reflect the metabolism, including the neuronal ones, in healthy and pathological conditions. A growing number of studies clearly demonstrate the effectiveness of VOCs analysis in identifying pathologies, including neurodegenerative diseases. In the present study we recorded, in real time, breath parameters and exhaled VOCs. We were able to demonstrate a significant alteration in breath parameters induced by the pathology of AD. Further, we provide the putative VOCs fingerprint of AD. These vital findings are an important step toward the early diagnosis of AD.
year | journal | country | edition | language |
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2015-01-01 |