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RESEARCH PRODUCT

HLA antigens in Sicilian patients affected by chronic myelogenous leukaemia.

C. Botindari And AndM. A. ModicaCalogero CarusoP. Lo Campo

subject

Genetic MarkersGenetic LinkageImmunologyHLA-DR6 AntigenHuman leukocyte antigenImmunogeneticsHLA-DR AntigensBiologylanguage.human_languageAntigenGene FrequencyHaplotypesItalyHLA Antigenshemic and lymphatic diseasesLeukemia Myelogenous Chronic BCR-ABL PositiveImmunologyGeneticsEtiologylanguageHumansRisk factorChronic myelogenous leukaemiaSicilian

description

SUMMARY HLA antigens were investigated in Sicilian patients with chronic myelogenous leukaemia (CML) and in Sicilian healthy controls. The frequency of the HLA-DRw6 antigen was significantly decreased in the group of patients. These results suggest that DRw6 may be a marker for decreased susceptibility to the etiological or pathogenic mechanism(s) which produce CMLs.

yearjournalcountryeditionlanguage
1987-12-01Journal of immunogenetics
10.1111/j.1744-313x.1987.tb00394.xhttps://pubmed.ncbi.nlm.nih.gov/3509755