6533b853fe1ef96bd12ad3e7

RESEARCH PRODUCT

Neuronal Nitric Oxide Synthase

Hartmut KleinertU. Förstermann

subject

chemistry.chemical_classificationmedicine.medical_specialtyMessenger RNACell typeCalmodulinbiologyATP synthaseChemistryNOS1biology.organism_classificationCell biologyEndocrinologyEnzymenervous systemEnosInternal medicinemedicinebiology.proteinNeuronal Nitric Oxide Synthase

description

Neuronal nitric oxides synthase (nNOS; also referred to as NOS1 or NOS I) is a low-output enzyme that is primarily expressed in neurons. Like eNOS, it is a low-output NOS whose activity is regulated by Ca++ and calmodulin, and that produces NO in a pulsatile fashion. nNOS has a widespread distribution in the central and peripheral nervous systems. In addition, nNOS mRNA transcripts and/or protein have also been detected in non-neuronal cell types, such as rhabdomyocytes, epithelial cells, mast cells, and neutrophils …

yearjournalcountryeditionlanguage
2007-01-01
https://doi.org/10.1016/b978-008055232-3.60508-2