6533b853fe1ef96bd12ad473
RESEARCH PRODUCT
Synthesis and antiviral activity of scopadulcic acids analogues
Ramón J. ZaragozáJuan G. Bueno-sanchezManuel ArnóMiguel A. GonzálezLiliana Betancur-galvissubject
ScopadulciolStereochemistryChemistryOrganic ChemistryDrug DiscoveryScopadulcic acid BOrganic chemistryBiochemistrydescription
The synthesis and antiviral properties of several scopadulcic acid analogues functionalized at C-6/C-7 and C-13 is reported. The preparation of advanced intermediates for the synthesis of scopadulcic acid B/scopadulciol analogues is also described. The biological study revealed the importance of polar groups at C-13, while the stereochemistry at C-8 was not critical for activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-08-01 | Tetrahedron |