6533b853fe1ef96bd12ad58b
RESEARCH PRODUCT
Effect of 3,4-dichloroaniline on the early life stages of the zebrafish (Brachydanio rerio): results of a comparative laboratory study.
B.b. Ter HöfteN. ScholzR. MunkRoland NagelM. MarkertN. CaspersP.-d. HansenH. Breschsubject
AgingAniline CompoundsbiologyHealth Toxicology and MutagenesisPublic Health Environmental and Occupational HealthTemperatureLiterGeneral MedicineHydrogen-Ion Concentrationbiology.organism_classificationPollutionEarly lifeAndrologyToxicologyExperimental animalchemistry.chemical_compoundInvestigation methodsFertilityMulticenter studychemistryAnimalsDichloroanilineZebrafishZebrafishdescription
An early life-stage (ELS) test was conducted with the zebrafish and 3,4-dichloroaniline (3,4-DCA) in eight laboratories. Based on the results from all eight laboratories, an LOEC of 200 micrograms 3,4-dichloroaniline/liter applies for the early life stages of the zebrafish. Effects observed were reduction of the survival rate and malformations. If the 100 micrograms/liter concentration additionally tested by one laboratory is included in the assessment, an LOEC of 100 micrograms 3,4-DCA/liter is obtained for the survival rate and increase in length. The NOEC is 20 micrograms/liter. The present results of a comparative laboratory study with the zebrafish show that a 42-day ELS test can be conducted with this species of fish, and affords meaningful results.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-04-01 | Ecotoxicology and environmental safety |