6533b853fe1ef96bd12ad5f0

RESEARCH PRODUCT

Flexible mats as promising antimicrobial systems via integration of Thymus capitatus (L.) essential oil into PLA

Andrea MaioMaurizio BrunoFrancesco LoprestiRoberto ScaffaroAntonia NostroAndreana MarinoManuela D'arrigo

subject

Microbiology (medical)Scanning electron microscope02 engineering and technology010402 general chemistry01 natural sciencesMicrobiologylaw.inventionchemistry.chemical_compoundfoodlawCytotoxicityEssential oilChromatographyantimicrobial activity; electrospun mats; essential oil; mechanical properties; vapor efficacyPetri dishtechnology industry and agricultureequipment and supplies021001 nanoscience & nanotechnologyAntimicrobialfood.foodElectrospinning0104 chemical sciencesLactic acidantimicrobial activity electrospun mats essential oil mechanical properties vapor efficacychemistryThymus capitatus0210 nano-technology

description

Aim: To develop electrospun mats loaded with Thymus capitatus (L.) essential oil ( ThymEO) and to study their morpho-mechanical and antimicrobial properties. Materials & methods: Poly(lactic acid) (PLA) mats containing ThymEO were prepared by electrospinning. The effect of ThymEO on the morpho-mechanical properties of fibers was assayed by scanning electron microscopy and dynamometer measurements. The antimicrobial activity of ThymEO delivered either in liquid or vapor phase was assessed through killing curves and invert Petri dishes method. The cytotoxicity was also investigated. Results: The mechanical properties were enhanced by integrating ThymEO into PLA. Both liquid and vapors of ThymEO released from mats caused reductions of microbial viable cells. Negligible cytotoxicity was demonstrated. Conclusion: PLA/ ThymEO delivery systems could be suitable for treating microbial infections.

yearjournalcountryeditionlanguage
2020-09-01Future Microbiology
https://doi.org/10.2217/fmb-2019-0291