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RESEARCH PRODUCT
Effect of aging on metabolic zonation in rat liver: acinar distribution of GSH metabolism.
Jose ViñaEsperanza GascoJose V. FerrerMiguel AsensiJuan SastreFederico PallardóJaime MiquelJoaquín V. Rodríguezsubject
Malemedicine.medical_specialtyAgingAntioxidantFree Radicalsmedicine.medical_treatmentGlutathione reductaseDehydrogenaseBiologyAntioxidantschemistry.chemical_compoundAcinusInternal medicineMalondialdehydemedicineAnimalsTissue DistributionGlutathione DisulfideRats Inbred StrainsGlutathioneMetabolismGlutathioneRatsmedicine.anatomical_structureEndocrinologychemistryLiverAgeingbiology.proteinDevelopmental BiologyPeroxidasedescription
The effect of age on the glutathione antioxidant system and its acinar distribution in rat liver was studied. GSH/GSSG ratio in blood and liver was lower in old than in young rats. Hepatic glutathione peroxidase and glutathione S-transferase activities were higher in old than in young rats, whereas hepatic gamma-glutamyl transpeptidase activity was lower in old than in young rats. Glutathione reductase and glucose-6-phosphate dehydrogenase activities did not change with age in rat liver. Total glutathione levels and glutathione peroxidase activity were higher in periportal than in perivenous areas of young rats, but this heterogeneous distribution did not occur in old rats. No change with age was found in hepatic zonation of glutathione reductase and glucose-6-phosphate dehydrogenase.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-02-01 | Mechanisms of ageing and development |