6533b853fe1ef96bd12add72

RESEARCH PRODUCT

New Insights and Recent Developments in Micellar Liquid Chromatography

subject

description

Abstract: Micellar liquid chromatography (MLC) is an efficient alternative to conventional reversed–phase liquid chromatography with hydro‐organic mobile phases. Almost three decades of experience have resulted in an increasing production of analytical applications. Current concern about the environment also reveals MLC as an interesting technique for “green” chemistry because it uses mobile phases containing 90% or more water. These micellar mobile phases have a low toxicity and are not producing hazardous wastes. After a rapid overview of the two first decades of the technique, this review focuses on the recent advances on fundamental aspects and analytical applications. Traditional and new surfactants, search of new organic solvents as mobile phase modifiers, and the use of new columns are addressed. Surfactant‐bonded phase association, combination of diverse surfactant effects, interaction between organic solvents and micelles, and resolution performance are also considered. A special attention has be...