6533b854fe1ef96bd12ae199
RESEARCH PRODUCT
Dual mixed-mode poly (vinylpyridine-co-methacrylic acid-co-ethylene glycol dimethacrylate)-based sorbent for acidic and basic drug extraction from oral fluid samples.
Francesc A. Esteve-turrillasJosé Manuel Herrero-martínezSergio ArmentaA. Sorribes-sorianosubject
SorbentPolymersEthylene glycol dimethacrylateInfrared spectroscopy02 engineering and technology01 natural sciencesBiochemistryAnalytical Chemistrychemistry.chemical_compoundEnvironmental ChemistrySolid phase extractionSpectroscopychemistry.chemical_classification010401 analytical chemistryExtraction (chemistry)Solid Phase ExtractionPolymer021001 nanoscience & nanotechnology0104 chemical scienceschemistryMethacrylic acidPolymerizationPharmaceutical PreparationsMethacrylates0210 nano-technologyNuclear chemistrydescription
Abstract In this study, a dual mixed-mode polymer sorbent was prepared via one-step thermally initiated polymerization of 4-vinylpyridine (VP), methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) for the solid-phase extraction (SPE) of basic and acidic drugs. The use of VP and MAA as ionizable functional monomers allowed the tailoring of ion-exchange and hydrophobic features of the polymer. The obtained polymer was characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. Next, the retention behavior of dual mixed-mode polymer towards basic and acidic drugs was investigated. Moreover, the practical capability of this novel material was tested for the extraction of relevant drugs such as cocaine, 3-methylmethcathinone, and diazepam in oral fluid samples. Recovery values (at different spiked levels in blank oral fluid samples), ranging from 69 to 99%, and limits of detection (LODs), between 0.10 and 0.25 μg L−1, were obtained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-02 | Analytica chimica acta |