6533b854fe1ef96bd12ae1c0

RESEARCH PRODUCT

Studies on the structure of coumarin-modified dextran nanoparticles by fluorescence spectroscopy.

Anne KotiahoPedro FardimThomas HeinzeThomas HeinzeHolger WondraczekMarja Niemi

subject

Polymers and PlasticsCycloaddition Reactionta221Organic ChemistryNanoparticleDextransPhotochemistryCoumarinFluorescenceFluorescence spectroscopySolventchemistry.chemical_compoundDextranUltraviolet visible spectroscopySpectrometry FluorescencechemistryCoumarinsMaterials ChemistryNanoparticlesheterocyclic compoundsAbsorption (chemistry)ta116

description

The photophysical and photochemical characteristics of nano-scaled particles obtained via solvent displacement from coumarin-modified dextrans were studied by means of absorption- and fluorescence-spectroscopy. The environment-dependent fluorescence emission of the pendant 4-methyl-7-alkoxy coumarin groups was exploited as a probe to gain information about the inner structure of the polysaccharide based nanoparticles. Time-resolved fluorescence measurements showed that the particles had two domains of different polarity and it could be confirmed that the core of the nano-assemblies contained water. Moreover, preliminary experiments were carried out demonstrating the possibility to control the morphology of the nanoparticles by the light induced 2π+2π cycloaddition of the coumarin substituents.

10.1016/j.carbpol.2013.04.040https://pubmed.ncbi.nlm.nih.gov/23769515