Radioaktīvo un smago metālu antidota jauna analoga izstrāde

6533b854fe1ef96bd12ae3db

RESEARCH PRODUCT

Radioaktīvo un smago metālu antidota jauna analoga izstrāde

subject

smagie metāli Farmācija antidots ferocianīds radioaktīvais piesārņojums cianoferāts

description

Pasaulē pieaug radioaktivitātes izmantošanas apjomi kā medicīnā, tā enerģijas ražošanā un šī sfēra saistās ar zināmiem riskiem, jo reti, taču regulāri notiek kodolincidenti. Tas ir iemesls veidot valsts rezerves, kurās ir antidoti iedzīvotāju pasargāšanai kodolincidentu gadījumā. Darba mērķis ir izstrādāt jaunu un efektīvāku dzelzs ferocianīda sintēzes shēmu salīdzinot ar šobrīd izmantotajām metodēm. Mērķa sasniegšanai tika optimizēta dzelzs ferocianīda sintēze izmantojot specifiskus sintēzes apstākļus, tai skaitā, specifisku reaģentu padošanas mehānismu, aktīvu maisīšanu, sintēzi ultraskaņas vannā un nesēja klātesamību, lai iegūtu iespējami augstvērtīgāku dzelzs ferocianīdu ar iespējami mazākām nanodaļiņām un ar iespējami augstāku saistīšanas kapacitāti, kas būtu ērti izmantojams, lai atbrīvotu organismu un vidi no radioaktīvā piesārņojuma. Lai paaugstinātu antidota efektivitāti, tika izveidots jauns zāļu sastāvs un izmantots kapsulas apvalks, kas atšķiras no tirgū pieejamā preparāta.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54718

PEPhysical Sciences and Engineering
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  - LS4_2Comparative physiology
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  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
  - LS3_16Functional imaging of cells and tissues
  - LS3_1Cell cycle, cell division and growth
  - LS3_2Cell senescence, cell death, autophagy, cell ageing
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  - LS5_11Neurological and neurodegenerative disorders
  - LS5_12Mental disorders
  - LS5_7Sensory systems, sensation and perception, including pain
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  - LS5_16Systems and computational neuroscience (e.g. modelling, simulation, brain oscillations, connectomics)
  - LS5_18Innovative methods and tools for neuroscience
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  - LS5_9Neural basis of cognition (e.g. learning, memory, attention, emotions, speech)
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  - LS5_8Neural basis of behaviour (e.g. sleep, consciousness, addiction)
  - LS5_4Neural stem cells
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SHSocial Sciences and Humanities
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