6533b854fe1ef96bd12ae77f
RESEARCH PRODUCT
Large-Scale Synthesis of Mammalian Gonadoliberin without protection of side-chain functions
Elzbieta MasiukiewiczBarbara Rzeszotarskasubject
chemistry.chemical_compoundChromatographyTetrapeptideChemistrySilica gelTotal efficiencySide chainCombinatorial chemistrydescription
A simple, Large-scale preparation of mammalian gonadoliberin was elaborated using classical solution methods without protecting side-chain functions. At the final stage, a hexapeptide segment was condensed with the corresponding tetrapeptide and the obtained decapeptide was purified by a single chromatographic procedure on silica gel. The total efficiency of the whole synthesis and the purity of the product amounted to 34% and 98.3%, respectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-01-01 | Journal f�r Praktische Chemie |