6533b854fe1ef96bd12ae7a7
RESEARCH PRODUCT
The reaction of optically active α-aminocarboxylic acid hydrazides with triethyl orthoesters
Agnieszka KudelkoWojciech ZielinskiKrzysztof Ejsmontsubject
Steric effectschemistry.chemical_compoundchemistryOrganic ChemistryDrug DiscoveryXyleneOptically activeBiochemistryMedicinal chemistrydescription
New derivatives of 2-(1-amino-1-phenylmethyl)-1,3,4-oxadiazole and 1,2,4-triazin-6-one were synthesised in the reactions of optically active α-aminocarboxylic acid hydrazides and triethyl orthoesters in xylene. The electronic and steric effects of substituents at the α position influencing the formation of five- or six-membered products are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-10-01 | Tetrahedron |