6533b854fe1ef96bd12ae9d4
RESEARCH PRODUCT
Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy.
Hong LiangDong YueZhongwei GuXiaobing ChenRongrong JinMatthias BarzQian JiangYu Niesubject
ChemistryGeneral EngineeringGeneral Materials ScienceBioengineeringGeneral ChemistryDelivery systemProdrugAnticancer drugCombinatorial chemistryAtomic and Molecular Physics and OpticsMultistage rocketdescription
An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-09-04 | Nanoscale advances |