6533b854fe1ef96bd12aea3d
RESEARCH PRODUCT
Improved technique for stereotactic placement of nerve grafts between two locations inside the rat brain
Carmen CabanesJosé Manuel García-verdugoFrancisco J. Sancho-bielsaMario SorianoUlises Gómez-pinedoSandra VidueiraM. Carmen FélezJuan A. Barciasubject
Central nervous systemNigrostriatal pathwayPeripheral nerve graftHost tissueStereotaxic TechniquesMicroscopy Electron TransmissionPeripheral nervemedicineAnimalsRegenerationNigrostriatal pathwaybusiness.industryGeneral NeuroscienceRegeneration (biology)Peripheral nerve graftsBrainAnatomyRat brainSciatic NerveNerve RegenerationRatssurgical procedures operativemedicine.anatomical_structureGrafting stereotactic cannulaStereotactic placementImplantbusinessdescription
Peripheral nerve grafts have shown the ability to facilitate central axonal growth and regenerate the adult central nervous system. However, the detailed description of a technique for atraumatic graft placement within the brain is lacking. We present a stereotactic procedure to implant a peripheral nerve graft within a rat's brain with minimal brain tissue damage. The procedure permits a correct graft placement joining two chosen points, and the survival and integration of the graft in the host tissue with a light glial reaction, with evidence of central axonal growth inside the graft, at least up to 8 weeks after its implantation. (C) 2008 Elsevier B.V. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 |