6533b854fe1ef96bd12aec32

RESEARCH PRODUCT

Noninvasive positive-pressure ventilation in ALS: predictors of tolerance and survival.

D. Lo CocoA. Lo CocoFederico PiccoliV. La BellaM. C. PescoSantino Marchese

subject

MaleNUTRITIONAL-STATUSmedicine.medical_specialtyVital capacityTime FactorsPositive pressureAMYOTROPHIC-LATERAL-SCLEROSISDISEASEPositive-Pressure RespirationFEV1/FVC ratioPredictive Value of TestsInternal medicineSickness Impact ProfilemedicineHumansSurvival rateLungAgedDemographyRetrospective StudiesVentilators Mechanicalbusiness.industryAmyotrophic Lateral SclerosisFUNCTIONAL RATING-SCALECAREMiddle AgedSurgeryRespiratory Function TestsSurvival RatePredictive value of testsRelative riskMultivariate AnalysisCardiologyBreathingFemaleNeurology (clinical)businessBody mass indexFollow-Up Studies

description

Objective: To identify factors associated with tolerance and survival after noninvasive positive-pressure ventilation (NIPPV) and to investigate the influence of NIPPV on lung function in patients with ALS. Methods: NIPPV was offered to 71 patients with ALS in accordance with currently published guidelines. Effects of NIPPV on lung function and factors influencing tolerance and survival after NIPPV were studied. Results: Forty-four patients (61.9%; 95% CI: 50.6 to 73.2) tolerated NIPPV (NIPPV use >= 4 h/day) and 27 (38.1%; 95% CI: 26.8 to 49.4) were intolerant (NIPPV use = 4 h/day) and to the modifications of forced vital capacity decline after treatment initiation. The severity of bulbar impairment and the nutritional status of the ALS patients at the introduction of ventilation may predict tolerance and survival.

yearjournalcountryeditionlanguage
2006-08-11Neurology
10.1212/01.wnl.0000227785.73714.64https://pubmed.ncbi.nlm.nih.gov/16899545