6533b854fe1ef96bd12af01d

RESEARCH PRODUCT

The value of immunohistochemical research on PCNA, p53 and heat shock proteins in prostate cancer management: a review.

F. CappelloA. RibbeneC. CampanellaAnna M. CzarneckaR. AnzaloneF. BucchieriA. PalmaG. Zummo

subject

MaleCell Transformation NeoplasticPCNA p53Proliferating Cell Nuclear AntigenBiomarkers TumorProstateAnimalsHumansProstatic NeoplasmsTumor Suppressor Protein p53ImmunohistochemistryPrecancerous ConditionsHeat-Shock Proteins

description

This review addresses the significance of the expression of proliferating cell nuclear antigen (PCNA), p53 and some heat shock proteins (Hsps) in prostate carcinoma (PC). In fact, PCNA and p53 are two widely discussed tools in PC diagno- sis, mainly because of the controversy regarding the signifi- cance of their expression during prostate cancer development and progression. At the same time, only few studies have shown the potential role of Hsps in carcinogenesis and their overexpression in pre-neoplastic and neoplastic lesions of the prostate. We briefly describe the physiological roles of Hsps in normal cells, and the significance of their immunohistochem- ical detection in PC as well as in pre-cancerous lesions of the prostate. We will also discuss the possible functional interac- tions of these molecules in both dysplastic and neoplastic cells

yearjournalcountryeditionlanguage
2006-04-06
http://europepmc.org/abstract/med/16584982