6533b854fe1ef96bd12af4b9

RESEARCH PRODUCT

Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe

A De LucaD DunnM ZazziR CamachoC TortiI FantiR KaiserA SönnerborgFm CodoñerK Van LaethemAm VandammeL BansiV Ghisetti Van De Vijver DaD AsboeMc ProsperiS Di GiambenedettoA De LucaD DunnM ZazziR CamachoC TortiI FantiR KaiserA SönnerborgFm CodoñerK Van LaethemAm VandammeL BansiV Ghisetti Van De Vijver DaD AsboeMc ProsperiS Di GiambenedettoSehere Collaboration In C. H. A. I. N. Collaborators: Giacometti AL ButiniR Del GobboS MenzoD TacconiG CorbelliS ZanussiL MonnoG PunziF MaggioloA CallegaroL CalzaR PristeràP TurconiA MandasS TiniA ZoncadaE PaoliniG AmadioL SighinolfiG ZuccatiM MorfiniR ManettiP CorsiL GalliM Di PietroF BartalesiG ColaoA TostiA Di BiagioM SettiB BruzzoneG PencoM TrezziA OraniR PardelliM De GennaroA ChioderaA ScalziniL PalvariniP AlmiG TodaroAd MonforteP CicconiS RusconiMr GismondoMr GismondoV MicheliMl BiondiN GianottiA CapettiP MeravigliaE BoeriC MussiniM PecorariA SoriaL VecchiM SantirocchiD BrustiaP RavaniniF Dal BelloN RomanoS MancusoC CalzettiR MaseratiG FiliceF BaldantiD FrancisciG ParrutiE PolilliD SacchiniC MartinelliRita Consolini

subject

MaleMultivariate analysisDatabases FactualDrug ResistanceHIV InfectionsDrug resistance0302 clinical medicineRetrospective StudieRisk FactorsEpidemiologyGenotypepol Gene Products Human Immunodeficiency ViruOdds RatioPrevalenceImmunology and AllergyHIV Infection030212 general & internal medicinepol Gene ProductsViralMultivariate Analysimedia_common0303 health sciencesDrug Resistance Prevalence HIV-1Middle AgedResistance mutation3. Good healthReverse Transcriptase InhibitorEuropeInfectious DiseasesReverse Transcriptase InhibitorsepidemiologyFemaleMultipleHuman Immunodeficiency VirusHumanDrugAdultmedicine.medical_specialtyGenotypeEvolutionmedia_common.quotation_subjectSexual Behaviorantiretroviral therapyInfectious DiseaseBiologySettore MED/17 - MALATTIE INFETTIVEEvolution Molecular03 medical and health sciencesDatabasesSDG 3 - Good Health and Well-beingDrug Resistance Multiple ViralmedicineHumansHIV Protease InhibitorFactualRetrospective Studies030306 microbiologyRisk FactorMolecularRetrospective cohort studyOdds ratioHIV Protease InhibitorsCD4 Lymphocyte Countantiretroviral therapy; drug resistance; epidemiology; genotyping; HIV-1; Adult; CD4 Lymphocyte Count; Databases Factual; Europe; Evolution Molecular; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Multivariate Analysis; Mutation; Odds Ratio; Prevalence; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Sexual Behavior; pol Gene Products Human Immunodeficiency Virus; Drug Resistance Multiple Viral; Immunology and Allergy; Infectious Diseasesgenotypingpol Gene Products Human Immunodeficiency VirusImmunologyMultivariate AnalysisMutationHIV-1Demography

description

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis. © 2013 The Author.

yearjournalcountryeditionlanguage
2013-01-01Journal of Infectious Diseases
10.1093/infdis/jit017http://dx.doi.org/10.1093/infdis/jit017