New Fluorinated 1,3-Vinylogous Amidines as Versatile Intermediates: Synthesis of Fluorinated Pyrimidin-2(1H)-ones.

6533b854fe1ef96bd12af542

RESEARCH PRODUCT

New Fluorinated 1,3-Vinylogous Amidines as Versatile Intermediates: Synthesis of Fluorinated Pyrimidin-2(1H)-ones.

Juan F. Sanz-cervera María Sánchez-roselló Jose Luis Acena Raquel Román Santos Fustero Benjamin H. Brodsky Julio Piera Carmen Ramírez De Arellano

subject

Turn (biochemistry)chemistry.chemical_compound Triphosgene Chemistry Yield (chemistry)Organic Chemistry Drug Discovery Condensation Organic chemistry General Medicine Biochemistry Pyrrole derivatives

description

The condensation of the azaenolates derived from readily available ketimines with fluorinated nitriles offers an efficient and straightforward entry to new fluorinated 1,3-vinylogous amidines. These versatile compounds, in turn, react with triphosgene to yield new fluorinated pyrimidin-2(1H)-ones in high yields.

year	journal	country	edition	language
2006-02-01	ChemInform

https://doi.org/10.1002/chin.200623161

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