6533b854fe1ef96bd12af68b
RESEARCH PRODUCT
Coumarin-Phosphine-Based Smart Probes for Tracking Biologically Relevant Metal Complexes: From Theoretical to Biological Investigations
Ewen BodioDenis JacqueminDenis JacqueminFranck DenatPierre Le GendreCatherine PaulCatherine PaulChristine GozeLucile DondaineLucile DondaineMoussa AliDaniel EscuderoAli BettaiebAli BettaiebPhilippe Richardsubject
ab-initiotheranosticschemistry.chemical_element010402 general chemistryPhotochemistry01 natural sciences[ CHIM ] Chemical SciencesQuantitative Biology::Cell BehaviorBioinorganic chemistryInorganic Chemistrychemistry.chemical_compound[CHIM]Chemical SciencesOsmiumSinglet statePhosphoniumtherapyAntitumor agents010405 organic chemistryChemistryLigandFluorescence0104 chemical sciencesRutheniumP ligandsagentsTheranostic agentsExcited stateFluorescent probesporphyrinPhosphinedescription
International audience; Ten metal-based complexes and associated ligands have been synthesized and characterized. One of the metal ligands is a coumarin-phosphine derivative, which displays tunable fluorescence properties. The fluorescence is quenched in the case of the free ligand and ruthenium and osmium complexes, whereas it is strong for the gold complexes and phosphonium derivatives. These trends were rationalized by theoretical calculations, which revealed non-radiative channels involving a dark state for the free ligands that is lower in energy than the emissive state and is responsible for the quenching of fluorescence. For the Ru-II and Os-II complexes, other non-radiative channels involving the manifold of singlet and triplet excited states may play a role. The anti-proliferative properties of all the compounds were evaluated in cancer cell lines (SW480, HCT116, MDA-MB-231 and MCF-7); higher IC50 values were obtained for gold(I) complexes, with the free ligands being only weakly cytotoxic.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-05 |