6533b855fe1ef96bd12afd5d
RESEARCH PRODUCT
ChemInform Abstract: Enantioselective Synthesis of α-Quaternary Amino Acids by Alkylation of Deprotonated α-Aminonitriles.
Isabelle NetzTill OpatzMurat Kucukdislisubject
chemistry.chemical_classificationChiral auxiliarychemistry.chemical_compoundHydrolysisDeprotonationchemistryStrecker amino acid synthesisEnantioselective synthesisGeneral MedicineAlkylationEnantiomeric excessMedicinal chemistryAmino aciddescription
An α-alkylation of deprotonated α-amino nitriles, prepared from chiral phenyldioxanamine (I) by Strecker reaction, leads to α-quaternary arylglycines with high optical purity after hydrolysis and oxidative cleavage of the chiral auxiliary.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-10-22 | ChemInform |