6533b855fe1ef96bd12b00a2
RESEARCH PRODUCT
Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy
Gennara CavallaroGiovanna PitarresiGaetano Giammonasubject
Macromolecular prodrugsStereochemistryMacromolecular SubstancesAntineoplastic AgentsGeneral MedicineGlutamic acidCombinatorial chemistryAntitumor therapyαβ-poly(N-2-hydroxyethyl)-DL-aspartamideαβ-polyaspartylhydrazide poly(glutamic acid) carrierchemistry.chemical_compoundanticancer drugsDrug Delivery SystemschemistryTargeted drug deliverySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPolylysineDrug DiscoveryAspartic acidDrug deliveryAnimalsHumansProdrugsAmino Acidsdescription
In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at proteinlike structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), α,β-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-09-01 |