6533b855fe1ef96bd12b07f1

RESEARCH PRODUCT

Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles for Drugs for Periodontitis Treatment: Development and Characterization

Fabio D'agostinoDenise MurgiaViviana De CaroGiuseppe Angellotti

subject

Isopropyl palmitateoral mucosal drug deliveryPolymers and PlasticsBioadhesiveSonicationbuccal matrix tabletsnanostructured lipid carriersbuccal matrix tablet02 engineering and technologynanostructured lipid carrier030226 pharmacology & pharmacyhydrophilic spongeArticlelcsh:QD241-44103 medical and health scienceschemistry.chemical_compound0302 clinical medicinemetronidazolelcsh:Organic chemistryPulmonary surfactantMucoadhesioncurcuminoral diseaseperiodontitisChromatographyChemistryGeneral ChemistryBuccal administrationPermeation021001 nanoscience & nanotechnologySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoNLCAnaerobic bacteria0210 nano-technologybuccal delivery

description

Periodontitis treatment is usually focused on the reduction or eradication of periodontal pathogens using antibiotics against anaerobic bacteria, such as metronidazole (MTR). Moreover, recently the correlation between periodontal diseases and overexpression of reactive oxygen species (ROS) led to the introduction of antioxidant biomolecules in therapy. In this work, bioadhesive buccal tablets, consisting of a hydrophilic matrix loaded with metronidazole and lipophilic nanoparticles as a vehicle of curcumin, were developed. Curcumin (CUR)-loaded nanostructured lipid carriers (NLC) were prepared using glycyrrhetic acid, hexadecanol, isopropyl palmitate and Tween&reg

yearjournalcountryeditionlanguage
2019-11-02
10.3390/polym11111801http://hdl.handle.net/10447/384640