6533b855fe1ef96bd12b0995

RESEARCH PRODUCT

Evaluation of biodegradability on polyaspartamide-polylactic acid based nanoparticles by chemical hydrolysis studies

Emanuela Fabiola CraparoGaetano GiammonaBarbara PorsioGennara CavallaroMaria Luisa Bondì

subject

Materials sciencePolymers and PlasticsNanoparticlemacromolecular substancesPolyethylene glycolchemistry.chemical_compoundHydrolysispoly(lactic acid) (PLA)Polylactic acid: ?biodegradability.Materials ChemistryOrganic chemistrytechnology industry and agriculturepoly(ethylene glycol) (PEG)BiodegradationCondensed Matter PhysicsLactic acidchemistry?-poly-(N-2-hydroxyethyl)-DL-aspartamide (PHEA)Mechanics of MaterialsYield (chemistry)graft copolymersnanoparticlesChemical stabilityNuclear chemistry

description

Here, the synthesis of two graft copolymers based on ?,?-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O'-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization-solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nanosystems was firstly confirmed by the reduction of the pH of the incubation medium. Moreover, the percentage yield of recovered nanoparticles show a gradual reduction while mean size increases as a function of incubation time. Degradation seems to be mainly attributed to the loss of water-soluble portions of PLA, and proceeds with greater speed at pH 5.5, than at pH 7.4 and as a function of matrix composition. KEYWORDS: ?,?-poly-(N-2-hydroxyethyl)-DL-aspartamide (PHEA), poly(lactic acid) (PLA), poly(ethylene glycol) (PEG), graft copolymers, nanoparticles, biodegradability.

yearjournalcountryeditionlanguage
2015-09-01Polymer Degradation and Stability
https://doi.org/10.1016/j.polymdegradstab.2015.05.003