6533b855fe1ef96bd12b11d5
RESEARCH PRODUCT
Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of Tregdevelopment
Ari WaismanPawel DurekNicole PuertasMir-farzin MashreghiMarianne R. SpalingerStefan FloessMirjam LutzEkaterina FriebelBenedict BecherFlorian IngelfingerFlorian MairFlorian MairAna AmorimClaudia HaftmannStefanie SchärliPascale ZwickyBurkhard BecherJochen HuehnRené RiedelJan KisielowBrian P. Leungsubject
medicine.anatomical_structureT cellImmunologyThymic epithelial cellmedicineCancer researchGeneral MedicineBiologymedicine.disease_causeAutoimmunitydescription
Medullary thymic epithelial cells (mTECs) are key antigen-presenting cells mediating T cell tolerance to prevent harmful autoimmunity. mTECs both negatively select self-reactive T cells and promote...
year | journal | country | edition | language |
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2021-11-26 | Science Immunology |