6533b855fe1ef96bd12b11d5

RESEARCH PRODUCT

Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of Tregdevelopment

Ari WaismanPawel DurekNicole PuertasMir-farzin MashreghiMarianne R. SpalingerStefan FloessMirjam LutzEkaterina FriebelBenedict BecherFlorian IngelfingerFlorian MairFlorian MairAna AmorimClaudia HaftmannStefanie SchärliPascale ZwickyBurkhard BecherJochen HuehnRené RiedelJan KisielowBrian P. Leung

subject

medicine.anatomical_structureT cellImmunologyThymic epithelial cellmedicineCancer researchGeneral MedicineBiologymedicine.disease_causeAutoimmunity

description

Medullary thymic epithelial cells (mTECs) are key antigen-presenting cells mediating T cell tolerance to prevent harmful autoimmunity. mTECs both negatively select self-reactive T cells and promote...

https://doi.org/10.1126/sciimmunol.abf3111