6533b855fe1ef96bd12b1224

RESEARCH PRODUCT

Regulatory (suppressor) T cells in peripheral allograft tolerance and graft-versus-host reaction.

Gérard RiflePatrick Hervé

subject

TransplantationGraft versus host reactionAllograft TolerancePeripheral toleranceGraft vs Host DiseaseDiseaseBiologyT-Lymphocytes RegulatoryPeripherallaw.inventionGraft vs Host ReactionlawImmunologyAllograft survivalSuppressorHumansTransplantation Tolerance

description

Among the mechanisms capable of inducing peripheral tolerance, regulatory (suppressor) T cells (Treg) probably play a key role in the control of both reactivity to self-antigens and alloimmune response. Augmentation or manipulation of Treg could improve organ allograft survival or control graft-versus-host disease, thus resulting in operational tolerance. The role of this immunomanipulation as one method of inducing tolerance has yet to be clearly defined.

yearjournalcountryeditionlanguage
2004-01-17Transplantation
10.1097/01.tp.0000107184.18562.fchttps://pubmed.ncbi.nlm.nih.gov/14726759