6533b855fe1ef96bd12b1248
RESEARCH PRODUCT
Androgen metabolism in the skin of the rainbow trout (Oncorhynchus mykiss)
M LatzR Reinbothsubject
medicine.medical_specialtyurogenital systemPhysiologyGeneral MedicineAquatic ScienceBiologyBiochemistrySex specificAndrogen Metabolism5α reductaseFisheryEndocrinologyInternal medicinemedicineFish <Actinopterygii>Rainbow troutTestosteronedescription
Pieces of skin of male and female rainbow trout (Oncorhynchus mykiss) were incubated with testosterone and 11-ketotestosterone as substrates. In immature fish the conversion rate was low. In non-spawning adult males 11-ketotestosterone was reduced to 5α-11KDHT (up to 5.2%). In the fish in spawning condition the 5α-reduction rate was only about 1 to 2%. In the same specimens incubated with testosterone a high 11β-hydroxylase activity (23.8-25% in the male and 13% in the female skin) was found. Similar sex specific differences were observed for the occurence of 5α-reduced metabolites (about 20% in the male and 13% in the female tissue).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-07-01 | Fish Physiology and Biochemistry |