6533b855fe1ef96bd12b1267
RESEARCH PRODUCT
Lateral differences in the GABAergic system of the rat striatum.
R. GuarneriG BettinazziP. GuarneriD ZarconeFederico PiccoliL Amatosubject
MaleRight striatumDermatologyStriatumSynaptic TransmissionRat striatumNeurochemicalPostsynaptic potentialBrain asymmetryAnimalsgamma-Aminobutyric AcidBinding SitesDiazepamChemistryGlutamate DecarboxylaseGeneral NeuroscienceRats Inbred StrainsGeneral MedicineCorpus StriatumRatsDissociation constantPsychiatry and Mental healthnervous system4-Aminobutyrate TransaminaseGABAergicNeurology (clinical)Neurosciencedescription
Asymmetric differences have been found in the pre- and postsynaptic activity of the GABAergic system of the left and right striata of the rat. 3H-GABA binding shows a higher dissociation constant (KD) and a higher number of sites (Bmax) in the left striatum than in the right. Moreover, 3H-diazepam binding seems to be more extensively activated by GABA in the right striatum suggesting a more sensitive postsynaptic GABAergic activity than on the left side. However, when the presynaptic marker (GAD activity) was measured, the asymmetry was in the opposite direction. The results provide further neurochemical evidence of the functional asymmetry of the rat brain.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-06-01 | Italian journal of neurological sciences |