6533b855fe1ef96bd12b1580
RESEARCH PRODUCT
Comparative investigations of hydroxyamine carane derivative and its R,S-diastereoisomers with strong local anesthetic activity
subject
carane derivativesanesthetic activitylidocainediastereoisomersdescription
Our previously conducted pharmacological screening led as to the discovery of the strong local anesthetic activity of the compound designated as KP-23. Earlier crystallographic studies revealed that the compound KP-23 crystallized in diastereoisomeric form in lowest symmetry. The aim of these comparative investigations was to evaluate anesthetic activity of KP-23 and its R,S-diastereoisomers, which were synthesized at the Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-01-01 | Polish Journal of Pharmacology |