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RESEARCH PRODUCT
Role of Th cytokines in thyroid autoimmunity
Maria Giovanna FrancipaneAttilio Ignazio Lo MonteMatilde TodaroGiorgio StassiY Lombardosubject
Settore MED/04 - Patologia GeneraleSettore MED/18 - Chirurgia GeneraleSettore BIO/16 - Anatomia UmanaTHYROID AUTOIMMUNE DESEASE CYTOKINEdescription
Thyroid autoimmunity occurs when the immune system reacts against thyroid cells after targeting them like any other “not-self” antigen. To define a thyroid autoimmune disorder is often difficult even if the presence of auto-antibodies and/or autoreactive lymphocytes is a common feature. Although the pathogenetic mechanism is poorly understood, increasing evidences indicate that apoptosis is one of the key process that leads to thyroid auto-immunity. Afterward, Th cytokines have been considered the regulator factors of the cell survival in thyroid autoimmunity. Understanding the cell response from the perspective of type 1 or type 2 cytokines could clarify the pathogenetic mechanism controlling thyroid autoimmunity and define new therapeutic approaches
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-01-01 |