Gold(I)-Catalyzed Reactions of 1-(ortho-Alkynylaryl)ureas: Highly Selective Heterocyclization and Synthesis of MixedN,O-Acetals

6533b856fe1ef96bd12b24d0

RESEARCH PRODUCT

Gold(I)-Catalyzed Reactions of 1-(ortho-Alkynylaryl)ureas: Highly Selective Heterocyclization and Synthesis of MixedN,O-Acetals

Ana Belen Cuenca Gregorio Asensio Ana Gimeno Mercedes Medio-simón

subject

Chemistry Organic chemistry Regioselectivity General Chemistry Hydroamination Highly selective Catalysis

description

Treatment of alkynylureas (I) with trifluoroethanol in the presence of a Au/Ag catalytic system provides N-6-exo-dig heterocyclization products (III) and in some cases open chain acetals as side products.

year	journal	country	edition	language
2014-01-08	Advanced Synthesis & Catalysis

https://doi.org/10.1002/adsc.201300730

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