6533b856fe1ef96bd12b274d
RESEARCH PRODUCT
Synthetic Haptens and Monoclonal Antibodies to the Cyanotoxin Anatoxin‐a
Josep V. MercaderGuillermo Quiñones-reyesGuillermo Quiñones-reyesAntonio Abad-somovillaAntonio Abad-fuentesConsuelo Agullósubject
Specific detectionmedicine.drug_classHarmful Algal BloomEnzyme-Linked Immunosorbent AssayAnimal poisoningBiology010402 general chemistryMonoclonal antibody01 natural sciencesAlgal bloomCatalysisAnatoxin-aMicrobiologychemistry.chemical_compoundmedicineAnimalsCyanobacteria Toxins010405 organic chemistryAntibodies MonoclonalSerum Albumin BovineStereoisomerismGeneral ChemistryCyanotoxin0104 chemical scienceschemistrybiology.proteinCattleAntibodyHaptensHaptenTropanesdescription
Early warning systems for monitoring toxic events may benefit from the availability of monoclonal antibodies enabling the sensitive and specific detection of anatoxin-a, a cyanotoxin involved in numerous cases of animal poisoning resulting from toxic algal blooms in freshwaters. Through the synthesis of three functionalized derivatives of anatoxin-a, we have succeeded in generating the first-ever reported immunoreagents (bioconjugates and antibodies) suitable for the development of immunoanalytical approaches aimed at rapid and onsite detection of this harmful cyanotoxin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-02 | Angewandte Chemie International Edition |