Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes

6533b856fe1ef96bd12b277a

RESEARCH PRODUCT

Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes

Maria Gkika Dimitrios G. Mikropoulos Vassilios Kozobolis Haris Sideroudi Georgios Labiris Irini Naoumidi Efthymia Tsaragli Stylliani Lydataki Stylliani Lydataki Alexandra Giatromanolaki Miguel A. Teus

subject

Male 0301 basic medicine Intraocular pressure medicine.medical_specialty Collagen cross linking genetic structures Ultraviolet Rays Intraocular pressure Riboflavin lcsh:Medicine Riboflavin Limbus Corneae Cornea 03 medical and health sciences 0302 clinical medicine Collagen fibres Ophthalmology Cornea medicine Animals Limbus Photosensitizing Agents business.industry lcsh:R Significant difference Corneal Crosslinking General Medicine eye diseases Cross-Linking Reagents 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Collagen Rabbits sense organs Central cornea business After treatment

description

The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.

year	journal	country	edition	language
2016-10-01	Acta Medica (Hradec Kralove, Czech Republic)

https://doi.org/10.14712/18059694.2016.96

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