6533b856fe1ef96bd12b27e0
RESEARCH PRODUCT
Autonomic nervous control of the urinary bladder
Karl-erik AnderssonMartin C. MichelBengt UveliusPeter Ochodnickysubject
medicine.medical_specialtyPhysiologyReceptor expressionUrinary Bladder030232 urology & nephrologyAdrenergicBiologyurologic and male genital diseasesAutonomic Nervous System03 medical and health sciences0302 clinical medicineInternal medicineMuscarinic acetylcholine receptorReceptors Adrenergic betamedicineAnimalsHumansUrotheliumUrinary bladderNeuronal PlasticityUrinary Bladder DiseasesMuscarinic acetylcholine receptor M3Receptors Muscarinicfemale genital diseases and pregnancy complicationsAutonomic nervous systemmedicine.anatomical_structureEndocrinology030217 neurology & neurosurgeryAcetylcholinemedicine.drugdescription
The autonomic nervous system plays an important role in the regulation of the urinary bladder function. Under physiological circumstances, noradrenaline, acting mainly on β(3) -adrenoceptors in the detrusor and on α(1) (A) -adrenoceptors in the bladder outflow tract, promotes urine storage, whereas neuronally released acetylcholine acting mainly on M(3) receptors promotes bladder emptying. Under pathophysiological conditions, however, this system may change in several ways. Firstly, there may be plasticity at the levels of innervation and receptor expression and function. Secondly, non-neuronal acetylcholine synthesis and release from the urothelium may occur during the storage phase, leading to a concomitant exposure of detrusor smooth muscle, urothelium and afferent nerves to acetylcholine and noradrenaline. This can cause interactions between the adrenergic and cholinergic system, which have been studied mostly at the post-junctional smooth muscle level until now. The implications of such plasticity are being discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | Acta Physiologica |