6533b856fe1ef96bd12b28a0
RESEARCH PRODUCT
Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam.
W. BorgiM.-c. RecioN. ChouchaneJ.l. Ríossubject
Analgesic activitymedicine.drug_classFlavonoidLotusNitrite productionSaponinPlant Sciencecomplex mixturesAnti-inflammatoryOxazolonechemistry.chemical_compoundAnti-inflammatory activitymedicinechemistry.chemical_classificationbiologyTraditional medicinefungifood and beveragesAlgesiabiology.organism_classificationDelayed type hypersensitivitycarbohydrates (lipids)chemistryBiochemistryZizyphus lotusvisual_artvisual_art.visual_art_mediumZiziphus lotusBarkdescription
Abstract The effect of the flavonoid and saponin fractions from the leaves and root bark of Zizyphus lotus (200 mg/kg) was evaluated on carrageenan-induced paw edema in rats and on acetic acid-induced algesia in mice. In addition, two methanolic extracts from the plant (1 mg/ear) were tested on oxazolone-induced contact-delayed hypersensitivity (DTH) in mice. The effect of the different fractions was also evaluated in vitro on the nitrite production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages. The results showed that both the flavonoid and saponin fractions significantly inhibited paw edema, algesia, and nitrite production without affecting cell viability. Furthermore, the methanolic extracts of the leaves and root bark of Z. lotus were found to significantly inhibit the DTH induced by oxazolone, with the extract obtained from root bark being more active than that obtained from leaves.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-04-01 | South African Journal of Botany |