Elpošanas ķēdes D - laktātdehidrogenāzes loma Zymomonas mobilis ndh-negatīvajā mutantā

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Elpošanas ķēdes D - laktātdehidrogenāzes loma Zymomonas mobilis ndh-negatīvajā mutantā

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Darbā konstruēts baktērijas Zymomonas mobilis negatīvais mutants Zm6-ndh-ldh, un pētīta šī celma aerobā augšana un elpošana.Darba mērķis bija pētīt D - laktāta dehidrogenāzes funkcijas šīs baktērijas elektronu transporta ķēdē. D - laktātdehidrogenāzes inaktivēšana pasliktina dubultmutanta aerobo augšanu, salīdzinot ar Zm6-ndh. Zm6-ndh-ldh inaktivētā elpošanas ķēdes laktātdehidrogenāze abos pārējos celmos darbojas laktāta patēriņa virzienā, par ko liecina laktāta uzkrāšanās dubultmutanta kultivēšanas vidē. Celmam Zm6-ndh-ldh piemīt lēnāks aerobās augšanas ātrums un nedaudz zemāks biomasas iznākums nekā celmam Zm6-ndh. Secināts, ka lēnā elpošanas ķēdes darbība, izmantojot D-laktātu kā elektronu avotu, varētu būt viens no faktoriem, kurš nosaka aerobās augšanas stimulāciju celmā Zm6-ndh.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/24932

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
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