6533b856fe1ef96bd12b2e8c
RESEARCH PRODUCT
ChemInform Abstract: Vinylogous and Coupled Hexahydroquinolinones and Dihydropyridines with Calcium-Modulating Effects.
Rose Usubject
Inotropemedicine.anatomical_structurechemistrymedicineBiophysicschemistry.chemical_elementIleumGeneral MedicineCalciumSpectral datadescription
The vinylogous, anellated and non-anellated dihydropyridines 4 and their coupled analogues 5 are accessible through Hantzsch-type cyclization reactions. IR, 1H-NMR, and mass spectral data are in agreement with the postulated structures. Pharmacological investigations on electrically-stimulated left atria of guinea pigs with some of the compounds gave rise to positive inotropic activities whereas BaCl2-induced contractions of the ileum were inhibited in a dose-dependent manner by some of the products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-12-25 | ChemInform |