6533b856fe1ef96bd12b2e92
RESEARCH PRODUCT
Simulations of the cultured granule neuron excitability
Tuula O. JalonenTuula O. JalonenMarja-leena Linnesubject
CerebellumQuantitative Biology::Neurons and CognitionChemistryCognitive NeuroscienceBiological neuron modelSmall neuronComputer Science Applicationsmedicine.anatomical_structureGranular cellnervous systemArtificial IntelligenceCalcium dynamicsmedicineBiological neural networkNeuronNeuroscienceIon channeldescription
Abstract We have developed a biophysical model of a cultured rat cerebellar granule neuron and simulated its excitability under different experimental conditions. The basic excitability properties of such a small neuron; the specific action potential waveforms, the overall firing patterns induced by current stimulations, and the linear frequency-current relation, are the main model constraints. Simulations show that for a one-compartmental granule neuron model, the constraints are met using six voltage- and time-dependent ion channel types and calcium dynamics linked to BK Ca ion channel function. This kind of model of a single neuron forms a solid basis for building the increasingly more complex network models of cultured neurons, and specifically for the cerebellar neuronal network.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-06-01 | Neurocomputing |