6533b856fe1ef96bd12b2f1a
RESEARCH PRODUCT
ChemInform Abstract: Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter.
Fares Ibrahim AmrM. Carmen MuñozGonzalo BlayCarlos VilaJosé R. Pedrosubject
chemistry.chemical_compoundBearing (mechanical)ThioureaChemistrylawEnantioselective synthesisPyrazolonesGeneral MedicineCombinatorial chemistryCatalysislaw.inventionStereocenterdescription
An efficient one-pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine-derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin-derived ketimines, providing the corresponding acetylated pyrazoles after in situ treatment with Ac2 O/Et3 N. The corresponding pyrazoles were afforded in high yields and excellent enantioselectivities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-01 | ChemInform |