6533b856fe1ef96bd12b310c

RESEARCH PRODUCT

THE RELATIONSHIP BETWEEN THE DIETARY INFLAMMATORY INDEX AND INCIDENT FRAILTY: A LONGITUDINAL COHORT STUDY

Stefania MaggiBrendon StubbsNitin ShivappaPatricia SchofieldJames R. HébertMatteo CesariNicola VeronesePinar Soysal

subject

Malemedicine.medical_specialtyAged; dietary inflammatory index; frailty; inflammationFrail Elderly030209 endocrinology & metabolismfrailtyRisk AssessmentArticleCohort Studies03 medical and health sciencesSex Factors0302 clinical medicineWeight lossInternal medicinemedicineHumans030212 general & internal medicineLongitudinal StudiesRisk factorGeriatric AssessmentGeneral NursingProportional Hazards ModelsAgedAged 80 and overFrailtybusiness.industryIncidenceHealth PolicyIncidence (epidemiology)Hazard ratioConfoundingAge FactorsGeneral MedicineOsteoarthritis KneePrognosisConfidence intervalDietQuartileinflammationNorth AmericaCohortPhysical therapydietary inflammatory indexFemaleIndependent LivingGeriatrics and Gerontologymedicine.symptombusinessOsteoporotic Fractures

description

Objective:\ud \ud Inflammation is key risk factor for several conditions in the elderly. However, the relationship between inflammation and frailty is still unclear. We investigated whether higher dietary inflammatory index (DII) scores were associated with higher incidence of frailty in a cohort of North Americans.\ud \ud Design:\ud \ud Longitudinal, with a follow-up of 8 years.\ud \ud Setting:\ud \ud Osteoarthritis Initiative.\ud \ud Participants:\ud \ud A total of 4421 participants with, or at high risk of, knee osteoarthritis.\ud \ud Measurements:\ud \ud DII scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and categorized into sex-specific quartiles. Frailty was defined as 2 out of 3 of the criteria of the Study of Osteoporotic Fracture study (ie, weight loss, inability to rise from a chair 5 times, and poor energy). The strength of the association between baseline DII score and incident frailty was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios.\ud \ud Results:\ud \ud A total of 4421 community-dwelling participants (2564 female participants; mean age: 61.3 years) without frailty at baseline were identified from the Osteoarthritis Initiative. During 8 years of follow-up, 356 individuals developed frailty (8.2%). Using Cox's regression analysis, adjusting for 11 potential confounders, participants with the highest DII score (quartile 4) had a significantly higher risk of experiencing frailty (hazard ratio 1.37; 95% confidence interval 1.01–1.89; P = .04) compared with participants with the lowest DII score (quartile 1). The association between DII score and frailty was significant only in men.\ud \ud Conclusions:\ud \ud Higher DII scores, indicating a more proinflammatory diet, are associated with higher incidence of frailty, particularly in men.

yearjournalcountryeditionlanguage
2017-09-21
10.1016/j.jamda.2017.08.006https://europepmc.org/articles/PMC5756582/