6533b856fe1ef96bd12b3127

RESEARCH PRODUCT

A possible role for cyclic guanosine monophosphate in the rat pineal gland.

A. SeidelA KantarjianLutz Vollrath

subject

Maleendocrine systemmedicine.medical_specialtyArylamine N-AcetyltransferaseBiologyPineal GlandPinealocytePineal glandCyclic nucleotidechemistry.chemical_compoundAcetyltransferasesInternal medicinemedicineAnimalsCyclic adenosine monophosphateCyclic guanosine monophosphateCyclic GMPMelatoninSynaptic ribbonGeneral NeurosciencefungiRats Inbred StrainsRatsbody regionsmedicine.anatomical_structureEndocrinologynervous systemchemistrySecond messenger systemSynapsessense organsEndocrine gland

description

Abstract Adrenergic stimulation of pinealocytes induces an increase of both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). However, for cGMP no biological effects have been demonstrated so far. Therefore we tested the effects of the analog 8-bromo-cGMP on synaptic ribbon numbers and on melatonin synthesis as reflected by N -acetyltransferase (NAT) activity in the rat pineal gland in vitro. Incubation for 6 h with 8-bromo-cGMP did not change the activity of serotonin NAT but in increased the number of synaptic ribbons. These results indicate that cGMP is involved as a second messenger in the regulation of synaptic ribbon numbers in the rat pineal gland.

yearjournalcountryeditionlanguage
1990-03-02Neuroscience letters
10.1016/0304-3940(90)90816-rhttps://pubmed.ncbi.nlm.nih.gov/2158018