6533b856fe1ef96bd12b32ac

RESEARCH PRODUCT

Preparation of ferulic acid derivatives and evaluation of their xanthine oxidase inhibition activity.

Leixiang YangXiao-jiang HaoXiaokun LiJoachim StöckigtKexin HuangYu ZhaoFeng Wang

subject

Xanthine OxidaseMagnetic Resonance SpectroscopyCoumaric Acidsmedicine.drug_classAllopurinolPositive controlPlant ScienceIn Vitro TechniquesInhibitory postsynaptic potentialBiochemistryAnalytical ChemistryFerulic acidElectron Transportchemistry.chemical_compoundmedicineOrganic chemistryAnimalsEnzyme InhibitorsXanthine oxidaseXanthine oxidase inhibitorIC50ChemistryOrganic ChemistryEstersNuclear magnetic resonance spectroscopyRatsLiverBenzaldehydesIndicators and Reagentsmedicine.drug

description

Several ferulic acid ethyl esters (3a-h) were synthesized under the Knoevengel reaction condition and they were further reduced to afford the respective allylic alcohol derivatives (4a-g). Some of them were evaluated for the xanthine oxidase (XO) inhibitory activity. Among them, 3h exhibited a significant inhibitory activity with an IC50 value of 1.35 x 10(-5) M, while the IC50 value of allopurinol used as the positive control was 1.49 x 10(-5) M. The study suggested that the higher acidity of the phenolic OH group in the ferulic acid derivatives might result in improved XO inhibitory activity.

yearjournalcountryeditionlanguage
2007-03-01Natural product research
10.1080/14786410601129648https://pubmed.ncbi.nlm.nih.gov/17365708