Trimetillizīna kvantitatīva noteikšana bioloģiskos paraugos ar šķidrumu hromatogfāfijas-masspektrometrijas metodi

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Trimetillizīna kvantitatīva noteikšana bioloģiskos paraugos ar šķidrumu hromatogfāfijas-masspektrometrijas metodi

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Darbā apkopota literatūra par trimetillizīna kvantitatīvās analīzes iespējām ar šķidrumu hromatogrāfijas metodēm. Izstrādāta un validēta jauna šķidrumu hromatogrāfijas – tandēmmasspektrometrijas metode trimetillizīna kvantitatīvai noteikšanai bioloģiskos paraugos, izmantojot derivatizāciju ar 6-aminohinolil-N-hidroksisukcīnimidilkarbamātu. Izstrādātā metode sekmīgi pielietota karnitīna biosintēzē iesaistīto savienojumu koncentrāciju mērījumiem žurku asins plazmā un audu homogenātos.

year	journal	country	edition	language
2012-01-01

https://dspace.lu.lv/dspace/handle/7/20882

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_10Atomic, molecular physics
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  - PE2_16Non-linear physics
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- PE1Mathematics
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  - PE10_13Physical geography, geomorphology
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- PE11Materials Engineering
  - PE11_2Engineering of metals and alloys
  - PE11_1Engineering of biomaterials, biomimetic, bioinspired and bio-enabled materials
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  - PE11_5Engineering of composites and hybrid materials
  - PE11_6Engineering of carbon materials
  - PE11_7Engineering of metal oxides
  - PE11_8Engineering of alternative established or emergent materials
  - PE11_9Nanomaterials engineering, e.g. nanoparticles, nanoporous materials, 1D & 2D nanomaterials
  - PE11_10Soft materials engineering, e.g. gels, foams, colloids
  - PE11_11Porous materials engineering, e.g. covalent-organic, metal-organic, porous aromatic frameworks
  - PE11_12Semi-conducting and magnetic materials engineering
  - PE11_13Metamaterials engineering
  - PE11_14Computational methods for materials engineering
LSLife Sciences
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  - LS1_11Chemical biology
  - LS1_12Protein design
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  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
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  - LS1_9Molecular mechanisms of signalling processes
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- LS2Integrative Biology: from Genes and Genomes to Systems
  - LS2_1Genetics
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  - LS4_1Organ and tissue physiology and pathophysiology
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  - LS4_3Physiology of ageing
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- LS3Cell Biology, Development, Stem Cells and Regeneration
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- LS5Neuroscience and Disorders of the Nervous System
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SHSocial Sciences and Humanities
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