6533b857fe1ef96bd12b3965
RESEARCH PRODUCT
The Preparation and Characterization of New Antazoline Salts with Dicarboxylic Acids
Andris ActiņšKristīne Krūkle-bērziņaAgnese DravnieceInese Sarcevicasubject
Fumaric acidMaleic acidHydrogen bondOxalic acidGeneral ChemistryCondensed Matter PhysicsOxalateSolventchemistry.chemical_compoundchemistryPolymorphism (materials science)Polymer chemistryAntazolinemedicineOrganic chemistryGeneral Materials Sciencemedicine.drugdescription
New antazoline salts with organic acids (fumaric acid, oxalic acid, and maleic acid) were prepared. The effect of the crystallization solvent and mechanochemical treatment on the crystalline forms of these salts was studied. Two polymorphs of antazoline hydrogen maleate were identified and their relative stability was determined. The molecular structures of antazoline hydrogen oxalate and antazoline hydrogen maleate showed differences in antazoline cation conformation. In crystal structures of all salts both imidazoline nitrogens of antazoline cation are involved in hydrogen bond formation with carboxyl groups of the acid.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-02 | Molecular Crystals and Liquid Crystals |