6533b857fe1ef96bd12b39d2

RESEARCH PRODUCT

Interferon-α for chronic hepatitis C: An analysis of pretreatment clinical predictors of response

Piero Luigi AlmasioAntonio CraxìOreste Lo IaconoVito Di MarcoLuigi PagliaroCalogero CammaáFabio Tinè

subject

medicine.medical_specialtyHepatologybusiness.industryAlpha interferonGastroenterologylaw.inventionRandomized controlled trialChronic hepatitislawInterferonInternal medicineInterferon αImmunologymedicineViral diseaseLymphoblastoid InterferonbusinessInterferon alfamedicine.drug

description

To identify predictors of short-term and sustained ALT normalization after interferon treatment in adult patients with chronic hepatitis C, we performed a metanalysis of individual patients'data, with construction and cross-validation of a prediction rule, in 361 patients from two randomized trials. In one trial, 116 subjects with transfusion-related chronic hepatitis C were treated with lymphoblastoid interferon (5 MU/m 2 three times a week for 2 mo, then 3 MU/m 2 three times a week for 4 or 10 mo)

yearjournalcountryeditionlanguage
1994-04-01Hepatology
https://doi.org/10.1002/hep.1840190404