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RESEARCH PRODUCT

Phylogenetic analysis of the thiolase family. Implications for the evolutionary origin of peroxisomes

J. DopazoJuan Carlos IgualCarmen González-boschJ. E. Perez-ortin

subject

SymbiogenesisMolecular Sequence DataSequence alignmentSaccharomyces cerevisiaeBiologyMicrobodiesHomology (biology)PhylogeneticsMolecular evolutionGeneticsAmino Acid SequenceAcetyl-CoA C-AcetyltransferaseSymbiosisThiolaseMolecular BiologyGenePhylogenyEcology Evolution Behavior and SystematicsGeneticsPhylogenetic treeThiolasePeroxisome evolutionBiological EvolutionEvolutionary biologyBootstrap analysisSequence Alignment

description

The thiolase family is a widespread group of proteins present in prokaryotes and three cellular compartments of eukaryotes. This fact makes this family interesting in order to study the evolutionary process of eukaryotes. Using the sequence of peroxisomal thiolase from Saccharomyces cerevisiae recently obtained by us and the other known thiolase sequences, a phylogenetic analysis has been carried out. It shows that all these proteins derived from a primitive enzyme, present in the common ancestor of eubacteria and eukaryotes, which evolved into different specialized thiolases confined to various cell compartments. The evolutionary tree obtained is compatible with the endosymbiotic theory for the origin of peroxisomes. © 1992, Springer-Verlag New York Inc. All rights reserved.

yearjournalcountryeditionlanguage
1992-08-01
10.1007/bf00183226https://hdl.handle.net/20.500.12792/5199