6533b857fe1ef96bd12b42db
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of Isoindolo[1,4]benzoxazinone and Isoindolo[1,5]benzoxazepine: Two New Ring Systems of Pharmaceutical Interest.
Alessandra MontalbanoPatrizia DianaAnna CarboneBarbara ParrinoPaola BarrajaVirginia SpanòCristina CianciminoGirolamo Cirrincionesubject
Human tumorchemistry.chemical_compoundchemistryGeneral MedicineIsoindoleRing (chemistry)Combinatorial chemistrydescription
Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM).
year | journal | country | edition | language |
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2016-01-01 | ChemInform |