6533b857fe1ef96bd12b42db

RESEARCH PRODUCT

ChemInform Abstract: Synthesis of Isoindolo[1,4]benzoxazinone and Isoindolo[1,5]benzoxazepine: Two New Ring Systems of Pharmaceutical Interest.

Alessandra MontalbanoPatrizia DianaAnna CarboneBarbara ParrinoPaola BarrajaVirginia SpanòCristina CianciminoGirolamo Cirrincione

subject

Human tumorchemistry.chemical_compoundchemistryGeneral MedicineIsoindoleRing (chemistry)Combinatorial chemistry

description

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM).

https://doi.org/10.1002/chin.201601183